Bioreactor Engineering 生物反应器工程

生物反应器工程是借鉴化学反应器工程而形成的一门课程。本课程通过定量的方式描述生物反应器中进行的生物过程，包括微生物细胞内的代谢反应以及能影响反应的条件，比如反应器内的质量传递、热量传递等。通过整合这些定量信息建立相应的模型用于研究不同反应器几何及操作条件对生物反应器性能的影响规律。这些知识可以用于生物反应器的优化及放大。该课程是欧盟Erasmus+计划BBChina项目（生物循环经济硕士项目：从田野到生物能源、生物燃料和生化制品）建设课程。

“Bioreactor Engineering” is a course adapted from “Chemical Reactor Engineering”. It tries to use a quantitative manner to describe the process that take place in the bioreactor including bioreactions in cell and processes that can influence the bioreactions, like mass transfer and heat transfer of the bioreactor. By combining all the quantitative information models will be developed to study the properties of bioreactors with various geometry or operation conditions etc. The knowledge can then be used to optimize and scale-up of the bioreactor. The course is developed by the Erasmus+ Capacity Building in Higher Education project “Master Program on Bio-Based Circular Economy: From Fields to Bioenergy, Biofuel and Bioproducts in China” (BBChina).

本课程以生物反应器及在其内进行的生物反应为核心，重点介绍细胞反应动力学理论、生物反应器传质混合研究、以及生物反应器的优化放大的国际最新研究进展。主要包括生物反应的计量学、生物反应中的热力学分析、细胞代谢通量分析、代谢控制分析、反应器流场动力学、传质模型、生物反应器放大等。通过本课程的学习，学生应具备进行生物反应器设计、性能分析、优化及放大的相关工程计算。

“Bioreactor Engineering” focuses mainly on bioreactor and bioreaction taken place in the bioreactor. It will mainly cover the bioreaction principles, mass mixing and transfer in bioreactor, as well as cut edge technologies in bioreactor optimization and scale-up internationally. The course will cover stoichiometry, thermodynamics of bioreaction, microorganism metabolic flux analysis, metabolic control analysis, fluid dynamics in bioreactors, mass transfer models and bioreactor scale-up etc. The students should have the ability to do bioreactor design, property analysis and optimization and scale-up calculations after learning this course.

Students completing this course will be able to:

• Form      the black box kinetics model of bioreactions.

• Using      the black box kinetics model to guide the gene modification of      microorganism

• Investigate      the mass transfer capacity of bioreactor and evaluate the bioreactor      bottlenecks for a real bioprocess

• Do      bioprocess optimization and scale-up of bioreactors